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PREreviews of “Higher-order epistasis creates idiosyncrasy, confounding predictions in protein evolution

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    1. Christian Macdonald
    2. James Fraser
    3. Sonya Lee

    Epistasis, a phenomenon where mutations interact rather than behaving independently, has long been of interest to biologists. In the molecular context, it describes a situation where the whole is different than the sum of its parts - that is, when the fitness effect of a set of mutations is not …

    Read the PREreview by Christian Macdonald et al.